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Physician Education: Pediatrics

Research Indicates Malignant Tumor Cells Masquerade as Endothelial Cells

Researchers at Children’s Hospital of Pittsburgh of UPMC recently discovered that tumor cells can differentiate into endothelial cells and may compromise the efficacy of chemotherapeutic drugs.   Based on this observation, researchers at Children’s Hospital are now investigating cell responses in tissue culture in the hope of identifying new drugs that may be more effective in the treatment of malignant tumors.

Using Normal Saline to Treat the Acutely Ill Child

Michael Moritz, MD, a nephrologist at Children’s Hospital of Pittsburgh of UPMC explains why, in many cases, administering normal saline solution to acutely ill children may reduce the likelihood of hyponatremia and hospital-based iatrogenic complications. 

Is Type 1 Diabetes Only One Disease?

Clinical findings and research are leading diabetes experts to the conclusion that Type 1 diabetes is actually a spectrum of diseases. Dorothy Becker, MD, chief, Pediatric Endocrinology and Diabetes at Children's Hospital of Pittsburgh of UPMC details research that may lead to the conclusion that Type 1 Diabetes has many different pathways and possibly, treatments.

Guidelines for Screening Newborns for Critical Congenital Heart Disease

Many hospitals are now embarking on steps to implement screening for critical congenital heart disease in their nurseries based on recommendations from the American Academy of Pediatrics and others.  To this end, experts at Children’s Hospital of Pittsburgh of UPMC offer input on how best to implement a pulse oximetry program.

Study Shows Telemedicine Effective in Delivering Cardiac Critical Care

A study conducted by Children's Hospital of Pittsburgh of UPMC and the Foundation Valle del Lili in Cali, Columbia confirmed that telemedicine in pediatric cardiac intensive care is not only feasible but effective.  Ricardo Munoz, MD, of Children's Hospital of Pittsburgh of UPMC explains.

Use of the VAD in Pediatric Heart Failure

Children in heart failure have very few options and very little time. In the past, transplantation was the only alternative. Doctors at Children's Hospital of Pittsburgh of UPMC have found that children placed on a ventricular assist device or VAD can either recover their own heart functions, eliminating the need for a transplant, or have more time to wait, should a transplant be needed. When a pediatric VAD is developed and approved, it's possible that this will become a destination therapy device for the management of heart failure in children.

Robotic-Assisted Pediatric Urology Surgery

Surgeons at Children's Hospital of Pittsburgh of UPMC are now routinely using a robot to assist in complicated bladder and renal reconstructive procedures. This robotic-assisted approach often results in less blood loss, less pain, and shorter recovery times.

New Studies to Enhance Medical Management of Liver Disease

Doctors at Children's Hospital of Pittsburgh of UPMC believe that the proper combination of medical and surgical therapy is the key to a successful outcome for children diagnosed with liver disease. They have recently launched two new clinical studies that may help combat the effects of liver disease. One studies ursodeoxycholic acid (URSO) for the treatment of primary sclerosing cholangitis and the other investigates the efficacy of carbamazepine in the treatment of A1AT deficiency.

Using the Endoscopic Endonasal Approach (EEA) in Children with Brain Tumors

EEA is a minimally invasive procedure in which neurosurgeons reach and remove lesions of the skull base through a natural pathway, the nose. Doctors at the Brain Care Institute of Children's Hospital of Pittsburgh of UPMC often use this approach to excise skull-based tumors in children as young as two years old. This multidisciplinary team of specialists has translated its knowledge and expertise in adult EEA into a model that can now benefit the pediatric population.

The Importance of Long Term Follow-Up of Pediatric Cancer Survivors

Because there are so many pediatric cancer survivors today, it is more important now than ever before that survival clinics exist. Doctors at Children's Hospital believe they have an obligation to educate survivors about their future so they can be armed with the necessary information to take charge of their health.